Article
Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activity
2019-06-27
Abstract excerpt
<h4>ABSTRACT</h4> Cytoplasmic dynein is a minus end-directed microtubule motor that transports myriad cargos in various cell types and contexts. How dynein is regulated to perform all these activities with a high degree of spatial and temporal precision is unclear. Recent studies have revealed that human dynein-1 and dynein-2 can be regulated by a mechanism of autoinhibition, whereby intermolecular contacts limit...
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Identifiers and source
- Literature Corpus work
- d1075a49-efcd-5f63-8396-b32a401a5e8d
- DOI
- 10.1101/684290