Article

Cryo-EM captures early intermediate steps in dynein activation by LIS1

2025-01-14

Abstract excerpt

Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited “Phi” state and requires conformational changes to assemble with its cofactors and form active transport complexes. LIS1, a key dynein regulator, enhances dynein activation and assembly. Using cryo-EM and a human dynein-LIS1 sample incubated with ATP, we mapped the conformational landscape...

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Literature Corpus work: ede4aee4-33f4-53ac-872e-97e5696ee23a
DOI: 10.1101/2025.01.10.632485

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