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Article

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.

The Journal of cell biology - 18 Mar 2002

Tai Chin-Yin, Dujardin Denis L, Faulkner Nicole E, Vallee Richard B

Abstract excerpt

Mutations in the human LIS1 gene cause type I lissencephaly, a severe brain developmental disease involving gross disorganization of cortical neurons. In lower eukaryotes, LIS1 participates in cytoplasmic dynein-mediated nuclear migration. We previously reported that mammalian LIS1 functions in cell division and coimmunoprecipitates with cytoplasmic dynein and dynactin. We also localized LIS1 to the cell cortex...

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Identifiers

PMID: 11889140
DOI: 10.1083/jcb.200109046
PMCID: PMC2173479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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