Article

Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedge

2022-10-11

Abstract excerpt

Cytoplasmic dynein-1 transports many intracellular cargos towards microtubule minus ends. Dynein is autoinhibited and undergoes conformational changes to form an active complex, consisting of one or two dynein dimers, the dynactin complex and activating adaptor(s) 1,2 . The Lissencephaly 1 gene, LIS1 , is genetically linked to the dynein pathway from fungi to mammals and is mutated in patients with the neurodeve...

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Literature Corpus work: e60204be-366d-5415-9d89-b19c7ea7a5c8
DOI: 10.1101/2022.10.10.511666

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