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Article

The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.

Biochimica et biophysica acta - 17 Mar 2000

Vallee R B, Faulkner N E, Tai C Y

Abstract excerpt

Lissencephaly is a brain developmental disorder characterized by disorganization of the cortical regions resulting from defects in neuronal migration. Recent evidence has implicated the human LIS-1 gene in Miller-Dieker lissencephaly and isolated lissencephaly sequence. LIS-1 is homologous to the fungal genes NudF and PAC1, which are involved in cytoplasmic dynein mediated nuclear transport, but it is also almost...

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PMID: 10722879
DOI: 10.1016/s0167-4889(00)00011-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.PMID 10722879Read ↗

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Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1Semantic proximity Read ↗

Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.Semantic proximity Read ↗

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