Article

Nde1 Promotes Lis1-Mediated Activation of Dynein

2023-05-26

Abstract excerpt

Cytoplasmic dynein is the primary motor that drives the motility and force generation functions towards the microtubule minus end. The activation of dynein motility requires its assembly with dynactin and a cargo adaptor. This process is facilitated by two dynein-associated factors, Lis1 and Nde1/Ndel1. Recent studies proposed that Lis1 rescues dynein from its autoinhibited conformation, but the physiological func...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3262a4ee-326f-5569-b92b-bfa65ea7a55f
DOI: 10.1101/2023.05.26.542537

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nde1 Promotes Lis1-Mediated Activation of DyneinDOI 10.1101/2023.05.26.542537Read

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.Semantic proximity Read

Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1Semantic proximity Read

Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read

Cryo-EM captures early intermediate steps in dynein activation by LIS1Semantic proximity Read

Cryo-EM captures early intermediate steps in dynein activation by LIS1.Semantic proximity Read

Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedgeSemantic proximity Read

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.Semantic proximity Read

LIS1 and dynein motor function in neuronal migration and development.Semantic proximity Read

NudEL targets dynein to microtubule ends through LIS1.Semantic proximity Read

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneinsSemantic proximity Read

Visualisation of dynein complexes in vitro and inside cellsSemantic proximity Read

Cytoplasmic dynein-2 at a glanceSemantic proximity Read