Article

Structures of human cytoplasmic dynein in complex with the lissencephaly 1 protein, LIS1

2022-10-08

Abstract excerpt

The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form. We recently reported a 3.1Å structure of yeast dynein bound to Pac1, the yeast homologue of LIS1, which revealed the details of their interactions (Gillies et al., 2022). Based on this struc...

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Literature Corpus work: 3373b703-5c87-5852-bb03-931b2ad93bc8
DOI: 10.1101/2022.10.08.511426

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