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Article

Cryo-EM captures early intermediate steps in dynein activation by LIS1.

Nature communications - 1 Aug 2025

Nguyen Kendrick H V, Karasmanis Eva P, Kendrick Agnieszka A, Reck-Peterson Samara L, Leschziner Andres E

Abstract excerpt

Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes. LIS1, a key dynein regulator, enhances dynein activation and assembly. Using cryo-EM and a human dynein-LIS1 sample incubated with ATP, we map the conformational landscape of...

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Identifiers

PMID: 40750582
DOI: 10.1038/s41467-025-62185-z
PMCID: PMC12317079

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