Article

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge

2022-11-07

Abstract excerpt

<title>Abstract</title> <p>Cytoplasmic dynein-1 transports many intracellular cargos towards microtubule minus ends. Dynein is autoinhibited and undergoes conformational changes to form an active complex, consisting of one or two dynein dimers, the dynactin complex and activating adaptor(s)<sup>1,2</sup>. The Lissencephaly 1 gene, <italic>LIS1</italic>, is genetically linked to the dynein pathway from fungi to ma...

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Literature Corpus work: a1d81d6a-0560-5c9f-a9a8-338b282a9bb1
DOI: 10.21203/rs.3.rs-2176420/v1

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