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Article

The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast.

The Journal of cell biology - 3 Feb 2003

Lee Wei-Lih, Oberle Jessica R, Cooper John A

Abstract excerpt

During mitosis in Saccharomyces cerevisiae, the mitotic spindle moves into the mother-bud neck via dynein-dependent sliding of cytoplasmic microtubules along the cortex of the bud. Here we show that Pac1, the yeast homologue of the human lissencephaly protein LIS1, plays a key role in this process. First, genetic interactions placed Pac1 in the dynein/dynactin pathway. Second, cells lacking Pac1 failed to display...

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Identifiers

PMID: 12566428
DOI: 10.1083/jcb.200209022
PMCID: PMC2172672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast.PMID 12566428Read ↗

The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex.Semantic proximity Read ↗

Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.Semantic proximity Read ↗

[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].Semantic proximity Read ↗

The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.Semantic proximity Read ↗

Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase.Semantic proximity Read ↗

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedgeSemantic proximity Read ↗

Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.Semantic proximity Read ↗

Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning.Semantic proximity Read ↗

Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedgeSemantic proximity Read ↗

Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast.Semantic proximity Read ↗

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.Semantic proximity Read ↗

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