Article

Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1

2021-06-11

Abstract excerpt

The lissencephaly 1 gene, LIS1 , is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor in many eukaryotes. Lis1 is the only dynein regulator that binds directly to dynein’s motor domain, and by doing so alters dynein’s mechanochemistry. Lis1 is requ...

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Literature Corpus work: d91aab80-fbf1-57bf-a512-84e58b1b0a41
DOI: 10.1101/2021.06.11.448119

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