Article

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

2025-06-25

Abstract excerpt

Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million single cells from blood and intestinal biopsies of 421 individuals, including 125 with inflammatory bowel disease (IBD). Cell-type-level eQTLs were more distal to transcription start sites, enriched in enhancers, less li...

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Literature Corpus work: 32045b11-2d86-541f-8c9b-6d621bcaad8a
DOI: 10.1101/2025.06.24.25330216

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