Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

Nature communications - 19 Nov 2021

Schmiedel Benjamin J, Rocha Job, Gonzalez-Colin Cristian, Bhattacharyya Sourya, Madrigal Ariel, Ottensmeier Christian H, Ay Ferhat, Chandra Vivek, Vijayanand Pandurangan

Abstract excerpt

Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Given the importance of immune cells in the pathogenesis of COVID-19 illness, here we assessed the effects of COVID-19-risk variants on gene expression in a wide range of immune cell types. Transcriptome-wide association study and colocalization analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Risk Factors

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 34799557
DOI: 10.1038/s41467-021-26888-3
PMCID: PMC8604964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.PMID 34799557Read ↗

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell typesSemantic proximity Read ↗

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative AnalysesSemantic proximity Read ↗

Human genetic variants associated with COVID-19 severity are enriched in immune and epithelium regulatory networksSemantic proximity Read ↗

Single cell sequencing analysis uncovers genetics-influenced CD16+monocytes and memory CD8+T cells involved in severe COVID-19Semantic proximity Read ↗

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19Semantic proximity Read ↗

Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort.Semantic proximity Read ↗

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19.Semantic proximity Read ↗

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionSemantic proximity Read ↗

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsSemantic proximity Read ↗

Integrative Transcriptomic Profiling of NK Cells and Monocytes: Advancing Diagnostic and Therapeutic Strategies for COVID-19Semantic proximity Read ↗

The evolutionary landscape of host immunity genes involved in respiratory and other immune-related diseases, and the identification of TLR2 variation associated with severe COVID-19.Semantic proximity Read ↗

The evolutionary landscape of host immunity genes involved in respiratory and other immune-related diseases, and their association with severe COVID-19 outcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.