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COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

Nature communications - 19 Nov 2021

Schmiedel Benjamin J, Rocha Job, Gonzalez-Colin Cristian, Bhattacharyya Sourya, Madrigal Ariel, Ottensmeier Christian H, Ay Ferhat, Chandra Vivek, Vijayanand Pandurangan

Abstract excerpt

Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Given the importance of immune cells in the pathogenesis of COVID-19 illness, here we assessed the effects of COVID-19-risk variants on gene expression in a wide range of immune cell types. Transcriptome-wide association study and colocalization analysis...

Topics

COVID-19
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Receptors, CCR
Risk Factors
T-Lymphocytes, Helper-Inducer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34799557
DOI: 10.1038/s41467-021-26888-3
PMCID: PMC8604964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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