Article

Gene expression and chromatin accessibility comparison in iPSC-derived microglia in African, European, and Amerindian genomes in Alzheimer’s patients and controls

2024-08-27

Abstract excerpt

Alzheimer’s disease (AD) risk differs between population groups, with African Americans and Hispanics being the most affected groups compared to non-Hispanic Whites. Genetic factors contribute significant risk to AD, but the genetic regulatory architectures (GRA) have primarily been studied in Europeans. Many AD genes are expressed in microglia; thus, we explored the impact of genetic ancestry (Amerindian (AI), Af...

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Literature Corpus work: 489d4ec0-ee0a-5c6f-9044-43d17a9a5a2b
DOI: 10.1101/2024.08.27.609943

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