Article

Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Diffuse intrinsic pontine glioma (DIPG) is a devastating brainstem cancer in children, with a median survival of under one year and limited treatment options. Over 80% of DIPGs possess a H3K27M mutation. To identify metabolic vulnerabilities linked to this mutation, we utilized a multi-omics approach in H3K27M-expressing cells, patient-derived cell lines, and mouse models. We show that by reprog...

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Literature Corpus work: d0b38af6-9a61-5aa9-ab00-41dfa573ad67
DOI: 10.1101/2025.05.21.655327

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