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Article

Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas.

Proceedings of the National Academy of Sciences of the United States of America - 2 May 2023

Mota Mateus, Sweha Stefan R, Pun Matt, Natarajan Siva Kumar, Ding Yujie, Chung Chan, Hawes Debra, Yang Fusheng, Judkins Alexander R, Samajdar Susanta, Cao Xuhong, Xiao Lanbo, Parolia Abhijit, Chinnaiyan Arul M, Venneti Sriram

Abstract excerpt

Diffuse midline gliomas (DMGs) including diffuse intrinsic pontine gliomas (DIPGs) bearing lysine-to-methionine mutations in histone H3 at lysine 27 (H3K27M) are lethal childhood brain cancers. These tumors harbor a global reduction in the transcriptional repressive mark H3K27me3 accompanied by an increase in the transcriptional activation mark H3K27ac. We postulated that H3K27M mutations, in addition to altering...

Topics

Humans
Child
Histones
Adenosine Triphosphatases
Diffuse Intrinsic Pontine Glioma
Lysine
Chromatin
Glioma
Brain Neoplasms
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Helicases

Nuclear Proteins

Transcription Factors

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Identifiers

PMID: 37094128
DOI: 10.1073/pnas.2221175120
PMCID: PMC10161095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37094128-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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