Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.

doi:10.1016/j.ccell.2020.07.008

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Article

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.

Cancer cell - 14 Sept 2020

Chung Chan, Sweha Stefan R, Pratt Drew, Tamrazi Benita, Panwalkar Pooja, Banda Adam, Bayliss Jill, Hawes Debra, Yang Fusheng, Lee Ho-Joon, Shan Mengrou, Cieslik Marcin, Qin Tingting, Werner Christian K, Wahl Daniel R, Lyssiotis Costas A, Bian Zhiguo, Shotwell J Brad, Yadav Viveka Nand, Koschmann Carl, Chinnaiyan Arul M, Blüml Stefan, Judkins Alexander R, Venneti Sriram

Abstract excerpt

H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments. They mainly harbor H3.3K27M mutations resulting in H3K27me3 reduction. Integrated analysis in H3.3K27M cells, tumors, and in vivo imaging in patients showed enhanced glycolysis, glutaminolysis, and tricarboxylic acid cycle metabolism with high alpha-ketoglutarate (α-KG) production. Glucose and/or glutamine-derived α-KG maintained low...

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PMID: 32795401
DOI: 10.1016/j.ccell.2020.07.008
PMCID: PMC7494613

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