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Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma

1 Jan 2023

Abstract excerpt

Diffuse midline glioma (DMG), hitherto known as diffuse intrinsic pontine glioma (DIPG), is a rare and aggressive form of brain cancer that primarily affects children. Although the exact cause of DMG/DIPG is not known, a large proportion of DMG/DIPG tumors harbor mutations in the gene encoding the histone H3 protein, specifically the H3K27M mutation. This mutation decreases the level of H3K27me3, a histone...

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PMID: 37151150
DOI: 10.14791/btrt.2023.0011

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