Article

Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma

2023-09-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K27M are characterized by altered metabolism and resistance to standard of care radiation (RT), but how the H3K27M mediates the metabolic...

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Literature Corpus work: 3a124fb7-6043-5c07-8aa3-fbd2b436dd2a
DOI: 10.21203/rs.3.rs-3317816/v1

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