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Article

Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG.

Epigenetics & chromatin - 19 May 2022

Lewis Nichole A, Klein Rachel Herndon, Kelly Cailin, Yee Jennifer, Knoepfler Paul S

Abstract excerpt

BACKGROUND: The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histone H3 post-translational modification (PTMs) and subsequent aberrant gene expression. However, much less is known about the effect this mutation has on chromatin structure and function, including...

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Identifiers

PMID: 35590427
DOI: 10.1186/s13072-022-00447-6
PMCID: PMC9121554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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