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Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma

19 Aug 2023

Abstract excerpt

Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis. While therapeutic histone deacetylase (HDAC) inhibition of diffuse intrinsic pontine glioma (DIPG) has been reported; here, we use a clinically relevant biopsy-derived hypermutant DIPG model (PBT-24FH) and a CRISPR-Cas9...

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Share to Glioma Diagnosis and Treatment
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PMID: 37603953
DOI: 10.1016/j.neo.2023.100921

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