Article

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

2021-12-01

Abstract excerpt

<h4>SUMMARY</h4> Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they appear less active in aggressive glioma, underscoring the need for alternative treatment strategies. Through a chemical synthetic lethality screen, we discovered that IDH1 mutant glioma cells are hypersensitive to drug...

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Literature Corpus work: 2882a2f7-aacd-54b2-acec-bf31bfa6c914
DOI: 10.1101/2021.11.30.470443

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