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Article

Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma.

Cancer research - 2 Jun 2025

Kong Yu, Wang Fan, Jing Renwei, Zhao Qian, Lv Xuejiao, Zhao Yingying, Yuan Ye, Xia Xianyou, Sun Yu, Tong Yujie, Yan Han, Li Qian, Li Ting, Cao Lei, Liu Deng, Huo Dawei, Sun Shao-Kai, Morís Francisco, Tang Yujie, Wu Xudong

Abstract excerpt

Diffuse intrinsic pontine gliomas (DIPG) are lethal pediatric brain tumors that frequently harbor H3K27M mutations and lack effective treatments. In this study, our epigenomic analyses uncovered an enrichment of specificity protein/Krüppel-like factor (SP/KLF) transcription factors in open chromatin regions specifically in H3K27M-mutated DIPG cells compared with normal pontine neural progenitor cells. SP1...

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PMID: 40053472
DOI: 10.1158/0008-5472.CAN-24-2227

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SP1

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