Article

A druggable addiction to <i>de novo</i> pyrimidine biosynthesis in diffuse midline glioma

2021-12-01

Abstract excerpt

<h4>SUMMARY</h4> Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development. To identify druggable targets for DMG, we conducted a genome-wide CRISPR screen that reveals a DMG selective dependency on the de novo pathway for pyrimidine biosynthesis. This metabolic vulnerability reflects an elevated rate of uridine/uracil degrad...

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Literature Corpus work: 73bf6c66-16dd-5589-84eb-dacb520ae10a
DOI: 10.1101/2021.11.30.470644

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