Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.

doi:10.1126/sciadv.abg4126

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.

Science advances - 1 Jun 2021

Wang Juan, Huang Tina Yi-Ting, Hou Ye, Bartom Elizabeth, Lu Xinyan, Shilatifard Ali, Yue Feng, Saratsis Amanda

Abstract excerpt

Pediatric high-grade gliomas (pHGGs), including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), are morbid brain tumors. Even with treatment survival is poor, making pHGG the number one cause of cancer death in children. Up to 80% of DIPGs harbor a somatic missense mutation in genes encoding histone H3. To investigate whether H3K27M is associated with distinct chromatin structure that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma
Share to Brain Stem Neoplasms
Share to Child
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 34078608
DOI: 10.1126/sciadv.abg4126
PMCID: PMC10166578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.