Article

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

2025-05-21

Abstract excerpt

<h4>SUMMARY</h4> The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and repeated treatment. Aberrant activity of striatal D1- and D2-expressing medium spiny neurons (D1-/D2-MSNs) underlies LID, but the mechanisms driving its progression remain unclear. Using the 6-OHDA mouse model of PD/LID,...

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Literature Corpus work: d0a86a8b-8b80-5046-9562-27432fc8c370
DOI: 10.1101/2025.05.16.654598

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