Article

Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function; Not a New Concept, but Neglected Reality Simmering in Striatal Stew

2023-12-12

Abstract excerpt

The mechanistic influences of dopamine (DA) signaling and impact on motor function is nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a standard practice in studies of human Parkinson’s disease (PD) and aging, and related animal models of PD and aging-related parkinsonism. However, despite dozens of studies indicating an ambiguous relationship between changes in striat...

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Literature Corpus work: 1616dc29-68a2-50ae-9304-ab52a4b5df5e
DOI: 10.20944/preprints202312.0834.v1

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