Article

Striatal cell-type–specific molecular signatures reveal therapeutic targets in a model of dystonia

2024-10-07

Abstract excerpt

Striatal dysfunction is implicated in many forms of dystonia, including idiopathic, inherited and iatrogenic dystonias. The striatum is comprised largely of GABAergic spiny projection neurons (SPNs) that are defined by their long-range efferents. Direct SPNs (dSPNs) project to the internal globus pallidus/substantia nigra reticulata whereas indirect pathway SPNs (iSPNs) project to the external pallidum; the concer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f0ab238-20b9-5b52-997d-ea797998d2c7
DOI: 10.1101/2024.10.07.617010

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Striatal cell-type–specific molecular signatures reveal therapeutic targets in a model of dystoniaDOI 10.1101/2024.10.07.617010Read

Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disordersSemantic proximity Read

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 <sup>G2019S</sup> model of Parkinson’s diseaseSemantic proximity Read

Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesiaSemantic proximity Read

Developmental, neuroanatomical and cellular expression of genes causing dystoniaSemantic proximity Read

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.Semantic proximity Read

A molecular atlas of cell-type specific signatures in the parkinsonian striatumSemantic proximity Read

A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate StriatumSemantic proximity Read

Translational profiling of neuronal subtypes in pre-symptomatic fatal familial insomnia mice reveals TOR signaling in somatostatin-expressing neuronsSemantic proximity Read

Translational profiling reveals novel gene expression changes in the direct and indirect pathways in a mouse model of LDOPA-induced dyskinesiaSemantic proximity Read

Transcriptomic analysis of dystonia-associated genes reveals functional convergence within specific cell types and shared neurobiology with psychiatric disordersSemantic proximity Read

Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression.Semantic proximity Read

A new knock-in mouse model of l-DOPA-responsive dystonia.Semantic proximity Read