Article

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

2024-04-10

Abstract excerpt

Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered in PD, but we understand little about if or how chronic changes in activity may contribute to degeneration. To address this question, we developed a chemogenetic (DREADD) mouse mo...

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Literature Corpus work: 7393ac3d-b417-5cb1-b5bf-861cf1f8f8b0
DOI: 10.1101/2024.04.05.588321

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