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Electroconvulsive Therapy Induces Dopaminergic Axon Regeneration, Corticostriatal Remodeling, and Restoration of Motor Function in Parkinsonian Mice

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is characterized by the progressive degeneration of midbrain dopaminergic neurons with loss of axonal dopamine neurotransmission in the dorsal striatum, leading to striatal circuit dysfunction and debilitating motor symptoms. Current therapies provide symptomatic relief but do not restore lost neuronal function. Decades of clinical observations have reported the unexpect...

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Literature Corpus work
ea7aee7f-9c41-5146-a9c5-e34fff1f8e6b
DOI
10.64898/2025.12.05.692581
Open publication

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