Article

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism

2026-06-02

Abstract excerpt

There are substantial functional changes in the primary motor cortex (M1) in Parkinson’s disease (PD). However, the temporal relationship between midbrain dopaminergic (DA) neurodegeneration, M1 circuit dysfunction, and Parkinsonian motor symptoms remains poorly understood. Using a genetic mouse model of progressive nigrostriatal DA degeneration (“MitoPark” mice), we determine the time course of M1 cellular dysfun...

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Literature Corpus work: bf52b800-9688-5089-a7f1-0bd2b3be66ec
DOI: 10.64898/2026.05.29.728524

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