Article

Time Course and Microcircuit Mechanisms of Primary Motor Cortex Dysfunction in Progressive Parkinsonism

2026-07-30

Abstract excerpt

Dysfunction of the primary motor cortex (M1) has long been implicated in the pathophysiology of Parkinson’s disease (PD), mostly as a link by which abnormal basal ganglia and thalamic activities are translated into motor symptoms. However, emerging evidence suggests that M1 neurons also exhibit maladaptive changes in advanced parkinsonism. Here, using a progressive mouse model of nigrostriatal neurodegeneration (i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15efdf64-efda-58cd-8867-81cbc89f6c7e
DOI: 10.64898/2026.07.27.741031

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Time Course and Microcircuit Mechanisms of Primary Motor Cortex Dysfunction in Progressive ParkinsonismDOI 10.64898/2026.07.27.741031Read

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive ParkinsonismSemantic proximity Read

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian MiceSemantic proximity Read

Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's diseaseSemantic proximity Read

Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neuronsSemantic proximity Read

Disruption of mitochondrial complex I induces progressive parkinsonism.Semantic proximity Read

Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion modelSemantic proximity Read

Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neuronsSemantic proximity Read

Motor cortex perineuronal net modulation improves motor function in a Parkinson’s disease mouse modelSemantic proximity Read

Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice.Semantic proximity Read

Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical-basal ganglia subcircuitSemantic proximity Read

LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.Semantic proximity Read

Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid-onset parkinsonian motor phenotype in mice.Semantic proximity Read