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Article

Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2017

Rose Samuel J, Harrast Porter, Donsante Christine, Fan Xueliang, Joers Valerie, Tansey Malú G, Jinnah H A, Hess Ellen J

Abstract excerpt

BACKGROUND: Recent neuroimaging studies implicate nigrostriatal degeneration as a critical factor in producing late-onset parkinsonism in patients with l-dopa-responsive dystonia-causing mutations. However, postmortem anatomical studies do not reveal neurodegeneration in l-dopa-responsive dystonia patients. These contrasting findings make it unclear how parkinsonism develops in l-dopa-responsive dystonia mutation...

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Identifiers

PMID: 28949038
DOI: 10.1002/mds.27169
PMCID: PMC5744486

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