Article

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

2024-02-02

Abstract excerpt

<h4>Summary</h4> Exercise training induces physiological cardiac hypertrophy, enhanced mitochondrial biogenesis and myocardial contractility. In skeletal muscle, the transcriptional coactivator PGC-1α is a key orchestrator of these responses. The heart expresses abundant and exercise-responsive PGC-1α, but it is unclear whether cardiomyocyte PGC-1α is necessary for cardiac adaptation to endurance training. Here w...

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Literature Corpus work: d054813f-2ea3-5f55-ad2f-1a462e103b97
DOI: 10.1101/2024.01.30.578093

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Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophyDOI 10.1101/2024.01.30.578093Read

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