Article

Inducible Impairment of Polymerase Gamma Activity in Cardiomyocytes Promotes Severe Cardiomyopathy with Cardiac Hepatopathy

2026-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction is a hallmark feature of heart failure (HF) and cardiomyopathy, with substantial human and preclinical evidence suggesting that congenital mitochondrial defects can directly drive these conditions. Despite these strong links, not all individuals with mitochondrial disease develop cardiomyopathy, and therefore the precise mitochondrial defects that initiate cardiac patho...

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Literature Corpus work: fc25140e-01b4-5b17-b6c4-9bc1fbde2eb4
DOI: 10.64898/2026.02.17.706486

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