Regulation of the Balance between Concentric and Eccentric Cardiac Hypertrophy by a CDC14A-KMT5A Signaling Pathway

Abstract excerpt

<h4>Background</h4> Depending upon the type of pathological stress, the heart undergoes concentric or eccentric remodeling. This structural change is associated with diastolic and/or systolic ventricular dysfunction reflecting differentially altered cardiomyocyte morphology, ultrastructure, metabolism, contractility, and survival, as well as interstitial myocardial fibrosis. Despite an association of both concent...

Topics

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• Cardiac electrophysiology and arrhythmias
• Cardiac Fibrosis and Remodeling
• Congenital heart defects research
• Down syndrome and intellectual disability research
• Histone Deacetylase Inhibitors Research
• Peptidase Inhibition and Analysis
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

041ea213-2d15-57be-942a-b1dbc4aebba0

DOI

10.64898/2026.02.16.706249