Article

Senescence and DNA Damage–Induced Inflammation Drive Heart Failure with Preserved Ejection Fraction in Cardiovascular Kidney Metabolic Syndrome

2026-04-16

Abstract excerpt

<h4>Introduction</h4> Heart failure with preserved ejection fraction (HFpEF) is strongly associated with cardiometabolic comorbidities, including obesity, diabetes, hypertension, chronic kidney disease and aging, yet the mechanistic contribution of cellular senescence to HFpEF pathogenesis remains poorly defined. <h4>Methods and Results</h4> To model clinically relevant HFpEF, we subjected p16-3MR mice to a nove...

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Literature Corpus work: 597910f4-7ab5-55c1-b7fd-55e24ed7b59c
DOI: 10.64898/2026.04.13.718331

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