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Article

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

15 Aug 2019

Abstract excerpt

Rationale: PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate PGC1α expression as a therapy, for instance, causing cardiomyopathy. Objective: To determine whether a fine-tuning of PGC1α expression is essential for cardiac homeostasis in a context-dependent...

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PMID: 31412728
DOI: 10.1161/circresaha.119.315529

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