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Article

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

The Journal of cell biology - 2 Jan 2017

Chung Hyo Kyun, Ryu Dongryeol, Kim Koon Soon, Chang Joon Young, Kim Yong Kyung, Yi Hyon-Seung, Kang Seul Gi, Choi Min Jeong, Lee Seong Eun, Jung Saet-Byel, Ryu Min Jeong, Kim Soung Jung, Kweon Gi Ryang, Kim Hail, Hwang Jung Hwan, Lee Chul-Ho, Lee Se-Jin, Wall Christopher E, Downes Michael, Evans Ronald M, Auwerx Johan, Shong Minho

Abstract excerpt

Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and -non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle-specific deficiency...

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Identifiers

PMID: 27986797
DOI: 10.1083/jcb.201607110
PMCID: PMC5223607

Genes

GDF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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