Article
Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling.
The Journal of physiology - 1 Dec 2016
Mutikainen Maija, Tuomainen Tomi, Naumenko Nikolay, Huusko Jenni, Smirin Boris, Laidinen Svetlana, Kokki Krista, Hynynen Heidi, Ylä-Herttuala Seppo, Heinäniemi Merja, Ruas Jorge L, Tavi Pasi
Abstract excerpt
KEY POINTS: Transcriptional co-activator PGC-1α1 has been shown to regulate energy metabolism and to mediate metabolic adaptations in pathological and physiological cardiac hypertrophy but other functional implications of PGC-1α1 expression are not known. Transgenic PGC-1α1 overexpression within the physiological range in mouse heart induces purposive changes in contractile properties, electrophysiology and...
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