Article

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunction

2025-11-13

Abstract excerpt

<h4>Background</h4> Cellular repressor of E1A-stimulated genes 1 (CREG1) is an evolutionarily conserved endolysosomal glycoprotein that enhances lysosomal biogenesis and autophagy, suppresses proliferation, and promotes differentiation. A prior gene targeting strategy that produced truncated N-terminal fragments resulted in embryonic lethality, limiting the ability to assess the physiological role of complete CRE...

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Literature Corpus work: 4f15f205-cf38-531d-a406-84111bb04721
DOI: 10.1101/2025.11.11.687936

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