FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.

doi:10.1152/ajpheart.00838.2020

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Article

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2021

Weeks Kate L, Tham Yow Keat, Yildiz Suzan G, Alexander Yonali, Donner Daniel G, Kiriazis Helen, Harmawan Claudia A, Hsu Amy, Bernardo Bianca C, Matsumoto Aya, DePinho Ronald A, Abel E Dale, Woodcock Elizabeth A, McMullen Julie R

Abstract excerpt

The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α (PI3K) are critical regulators of exercise-induced physiological cardiac hypertrophy and provide protection in experimental models of pathological remodeling and heart failure. Forkhead box class O1 (FoxO1) is a transcription factor that regulates cardiomyocyte hypertrophy downstream of IGF1R/PI3K activation in vitro, but its...

Topics

Animals
Cardiomegaly
Cardiomegaly, Exercise-Induced
Class I Phosphatidylinositol 3-Kinases
Enzyme Activation
Female
Fibrosis
Forkhead Box Protein O1
Forkhead Box Protein O3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

HSP70 Heat-Shock Proteins

Male

Mice, Knockout

Myocytes, Cardiac

Phenotype

Phosphorylation

Proto-Oncogene Proteins c-akt

Receptor, IGF Type 1

Source

Open in PubMed

Identifiers

PMID: 33577435
DOI: 10.1152/ajpheart.00838.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.PMID 33577435Read ↗

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