Article

Increased CPT1a expression is a critical cardioprotective response to pathological stress that suppresses gene programs for remodeling and enables rescue by gene transfer

2024-10-02

Abstract excerpt

<h4>Text Abstract</h4> <h4>Background</h4> Carnitine palmitoyl transferase 1 (CPT1) is a rate-limiting enzyme for long chain fatty acid oxidation (FAO) in cardiac mitochondria. In adult hearts, CPT1b predominates, while CPT1a is co-expressed at lower levels. Pathological stress on the heart induces greater CPT1a expression, and this coincides with a reduction in FAO, yet the role of CPT1a in pathological cardiac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b547e7a-cc56-5a8a-9871-78bf2f2a4e7f
DOI: 10.1101/2024.09.30.615965

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased CPT1a expression is a critical cardioprotective response to pathological stress that suppresses gene programs for remodeling and enables rescue by gene transferDOI 10.1101/2024.09.30.615965Read

PERM1 Gene Delivery via AAV Prevents Heart Failure in a Mouse Model of Pressure OverloadSemantic proximity Read

Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy.Semantic proximity Read

Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy.Semantic proximity Read

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophySemantic proximity Read

TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.Semantic proximity Read

miR-378a Controls Cardiomyocyte Metabolism and Angiogenic SignalingSemantic proximity Read

Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy via encoding a novel protein FTO-36aaSemantic proximity Read

ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδSemantic proximity Read

Transverse Aortic COnstriction Multi-omics Analysis (TACOMA) uncovers pathophysiological cardiac molecular mechanismsSemantic proximity Read

Gene Therapy Mediates Therapeutic Improvement in Cardiac Hypertrophy and Survival in a Murine Model of <i>MYBPC3</i> -Associated CardiomyopathySemantic proximity Read

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunctionSemantic proximity Read

OPA1 mediates cardiac function and metabolism: in silico and in vivo evidenceSemantic proximity Read