Article

Apolipoprotein E moderates the association between Non-<i>APOE</i>Polygenic Risk Score for Alzheimer’s Disease and Aging on Preclinical Cognitive Function

2023-06-12

Abstract excerpt

<h4>INTRODUCTION</h4> Variation in preclinical cognitive decline suggests additional genetic factors related to Alzheimer’s disease (e.g., a non- APOE polygenic risk scores [PRS]) may interact with the APOE ε4 allele to influence cognitive decline. <h4>METHODS</h4> We tested the PRSξ APOE ε4ξage interaction on preclinical cognition using longitudinal data from the Wisconsin Registry for Alzheimer’s Prevention. All...

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Literature Corpus work: d050ef5a-8a18-5f8f-be40-d9727818c314
DOI: 10.1101/2023.06.09.23291215

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