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Article

Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition.

Neurology - 1 May 2018

Ge Tian, Sabuncu Mert R, Smoller Jordan W, Sperling Reisa A, Mormino Elizabeth C

Abstract excerpt

OBJECTIVE: To investigate the effects of genetic risk of Alzheimer disease (AD) dementia in the context of β-amyloid (Aβ) accumulation. METHODS: We analyzed data from 702 participants (221 clinically normal, 367 with mild cognitive impairment, and 114 with AD dementia) with genetic data and florbetapir PET available. A subset of 669 participants additionally had longitudinal MRI scans to assess hippocampal...

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Identifiers

PMID: 29592889
DOI: 10.1212/WNL.0000000000005415
PMCID: PMC5931806

Genes

APOE

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