Age‐dependent effects of <i>APOE</i> ε4 in preclinical Alzheimer's disease

doi:10.1002/acn3.333

Article

Age‐dependent effects of <i>APOE</i> ε4 in preclinical Alzheimer's disease

26 Aug 2016

Abstract excerpt

OBJECTIVE: The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD. METHODS: Using data from 5381 cognitively normal older individuals and Cox proportional hazards models, we...

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