Article

Neuropathology-based<i>APOE</i>genetic risk score better quantifies Alzheimer’s risk

2022-10-13

Abstract excerpt

<h4>INTRODUCTION</h4> APOE ε4 -carrier status or ε4 allele count are included in analyses to account for the APOE genetic effect on Alzheimer’s disease (AD); however, this does not account for protective effects of APOE ε2 or heterogeneous effect of ε2, ε3, ε4 haplotypes. <h4>METHODS</h4> We leveraged results from an autopsy-confirmed AD study to generate a weighted risk score for APOE ( APOE -npscore). We regress...

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Literature Corpus work: bb2b9a6e-d8a7-50e9-9846-b4024b27aff9
DOI: 10.1101/2022.10.12.22280874

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