Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.

doi:10.1186/s13195-023-01206-9

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Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.

Alzheimer's research & therapy - 28 Mar 2023

Pettigrew Corinne, Nazarovs Jurijs, Soldan Anja, Singh Vikas, Wang Jiangxia, Hohman Timothy, Dumitrescu Logan, Libby Julia, Kunkle Brian, Gross Alden L, Johnson Sterling, Lu Qiongshi, Engelman Corinne, Masters Colin L, Maruff Paul, Laws Simon M, Morris John C, Hassenstab Jason, Cruchaga Carlos, Resnick Susan M, Kitner-Triolo Melissa H, An Yang, Albert Marilyn

Abstract excerpt

BACKGROUND: Both Alzheimer's disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition. METHODS: Analyses used data from the...

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PMID: 36978190
DOI: 10.1186/s13195-023-01206-9
PMCID: PMC10045505

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