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Article

Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease.

Neurology - 20 May 2014

Mormino Elizabeth C, Betensky Rebecca A, Hedden Trey, Schultz Aaron P, Ward Andrew, Huijbers Willem, Rentz Dorene M, Johnson Keith A, Sperling Reisa A

Abstract excerpt

OBJECTIVE: To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN). METHODS: Data from 490 CNs were aggregated across 3 observational cohort studies (Harvard Aging Brain Study, Alzheimer's Disease Neuroimaging Initiative, and Australian Imaging Biomarkers and Lifestyle Study of Ageing; median...

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Identifiers

PMID: 24748674
DOI: 10.1212/WNL.0000000000000431
PMCID: PMC4035706

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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