Article
Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.
BMC neurology - 15 Dec 2022
Tomassen Jori, den Braber Anouk, van der Lee Sven J, Reus Lianne M, Konijnenberg Elles, Carter Stephen F, Yaqub Maqsood, van Berckel Bart N M, Collij Lyduine E, Boomsma Dorret I, de Geus Eco J C, Scheltens Philip, Herholz Karl, Tijms Betty M, Visser Pieter Jelle
Abstract excerpt
BACKGROUND: What combination of risk factors for Alzheimer's disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype, AD-Polygenic Risk Scores (AD-PRS), amyloid-β pathology and decline in cognitive functioning over time in a large sample of cognitively unimpaired older individuals. METHODS: We included 276...
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